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FX-909

CAT: 0013-GTR19212037-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212037-01Size:1 mg
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Description
FX-909 is a covalent PPARγ inverse agonist used in cancer research. It has demonstrated activity in both in vitro cellular assays and in vivo preclinical models, supporting its investigation in oncology-related studies.
CAS Number
2924573-90-8
Field of Research
Metabolism Research, Molecular Biology
Purity
99.53% (May vary between batches)
Smiles
N#CC=1C=CC (=C (C1) C2=CC (=O) C=3C (F) =CC (F) =CC3N2) S (=O) (=O) C
Molecular Formula
C17H10F2N2O3S
Molecular Weight
360.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-(5,7-Difluoro-4-oxo-1,4-dihydroquinolin-2-yl)-4-(methylsulfonyl)benzonitrile

PPAR Gamma Inhibitor FX-909 is an orally available inverse agonist and inhibitor of the transcription factor (TF) peroxisome proliferator-activated receptor gamma (PPAR gamma; PPARG), with potential antineoplastic activity. Upon oral administration, PPARG inhibitor FX-909 selectively targets and covalently binds to a region of PPARG that is sequestered from the mutation site. The binding promotes a repressive conformation of PPARG and inhibits the activity of PPARG. This inhibits both basal- and ligand-activated transcription by PPARG and prevents PPARG-mediated transcription of target genes, such as FABP4/Fabp4, AGT/Agt, IVT/Ivd and ARG1/Arg1. This may inhibit proliferation in PPARG-overactivated tumor cells. PPARG, a nuclear receptor, is genetically altered, including amplification, missense mutations, and fusions, in certain tumor cells commonly associated with the luminal lineage subtype.

CAS Number2924573-90-8
PubChem CID167993670
IUPAC Name3-(5,7-difluoro-4-oxo-1H-quinolin-2-yl)-4-methylsulfonylbenzonitrile
Molecular FormulaC17H10F2N2O3S
Molecular Weight360.3
XLogP2.4
Topological Polar Surface Area95.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity737
SMILES
CS(=O)(=O)C1=C(C=C(C=C1)C#N)C2=CC(=O)C3=C(N2)C=C(C=C3F)F
InChI
InChI=1S/C17H10F2N2O3S/c1-25(23,24)16-3-2-9(8-20)4-11(16)13-7-15(22)17-12(19)5-10(18)6-14(17)21-13/h2-7H,1H3,(H,21,22)
InChIKey
RBUBBZVQPHSZEZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(5,7-Difluoro-4-oxo-1,4-dihydroquinolin-2-yl)-4-(methylsulfonyl)benzonitrile
CAS: 2924573-90-8
CID: 167993670
Formula: C17H10F2N2O3S
MW: 360.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight360.3
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass360.03801968
Monoisotopic Mass360.03801968
Topological Polar Surface Area95.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity737
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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