Tenifatecan

CAT: 0013-GTR19211828-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19211828-01Size:1 mg

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Description

Tenifatecan (SN2310) is a lipophilic derivative of the camptothecin analog SN-38, designed to enhance cellular uptake. It acts as a topoisomerase I inhibitor, demonstrating potent antitumor activity in both in vitro cytotoxicity assays and in vivo xenograft models across various cancer types.

CAS Number

850728-18-6

Product Name Alternative

SN 2310, SN2310, SN-2310, Tenifatecan

Field of Research

Molecular Biology

Purity

98.05% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:< 1 mg/mL (insoluble or slightly soluble)

Smiles

C (C) C1=C2C (C=3N (C2) C (=O) C4=C (C3) [C@] (CC) (O) C (=O) OC4) =NC=5C1=CC (OC (CCC (OC=6C (C) =C7C (=C (C) C6C) O[C@@] (CCC[C@@H] (CCC[C@@H] (CCCC (C) C) C) C) (C) CC7) =O) =O) =CC5

Molecular Formula

C55H72N2O9

Molecular Weight

905.17

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Tenifatecan

Tenifatecan is a highly lipophilic preparation of 7-Ethyl-10-hydroxycamptothecin (SN-38) with potential antineoplastic activity. SN2310 is an oil-in-water emulsion of tocopherol covalently linked, via a succinate linker, to SN-38, a synthetic derivative of the cytotoxic alkaloid camptothecin. After succinate linker is hydrolyzed in vivo, the active moiety SN-38 is released and selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks and inducing lethal double-stranded DNA breaks. This inhibits DNA replication and triggers programmed cell death. SN2310 emulsion provides longer circulation time and potentiates drug exposure as compared to the unconjugated SN-38.

CAS Number	850728-18-6
PubChem CID	11251571
IUPAC Name	1-O-[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-O-[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] butanedioate
Molecular Formula	C55H72N2O9
Molecular Weight	905.2
XLogP	12
Topological Polar Surface Area	142
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	21
Heavy Atom Count	66
Formal Charge	0
Complexity	1810

SMILES

CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)CCC(=O)OC6=C(C7=C(C(=C6C)C)O[C@](CC7)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C

InChI

InChI=1S/C55H72N2O9/c1-11-39-41-28-38(21-22-45(41)56-49-42(39)30-57-46(49)29-44-43(52(57)60)31-63-53(61)55(44,62)12-2)64-47(58)23-24-48(59)65-50-35(7)36(8)51-40(37(50)9)25-27-54(10,66-51)26-15-20-34(6)19-14-18-33(5)17-13-16-32(3)4/h21-22,28-29,32-34,62H,11-20,23-27,30-31H2,1-10H3/t33-,34-,54-,55+/m1/s1

InChIKey

KRHZRBUSQSYTTP-PTXGIJCNSA-N

Chemical Structure

2D Structure

CAS: 850728-18-6

CID: 11251571

Formula: C55H72N2O9

MW: 905.2

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	905.2
XLogP3	12
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	21
Exact Mass	904.52378188
Monoisotopic Mass	904.52378188
Topological Polar Surface Area	142 Å²
Heavy Atom Count	66
Formal Charge	0
Complexity	1810
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-14871-01	Tenifatecan

Tenifatecan

Chemical Information

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