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Mafosfamide

CAT: 0013-GTR19211543-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19211543-03Size:100 mg
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Description
Mafosfamide is an alkylating antineoplastic agent that directly forms DNA cross-links without requiring metabolic activation, distinguishing it from cyclophosphamide. This property supports its research application in models of neoplastic meningitis, including in vitro cytotoxicity assays and in vivo intrathecal delivery studies.
CAS Number
88859-04-5
Smiles
N (CCCl) (CCCl) P1 (=O) N[C@H] (SCCS (=O) (=O) O) CCO1
Molecular Formula
C9H19Cl2N2O5PS2
Molecular Weight
401.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mafosfamide

Mafosfamide has been used in trials studying the treatment of Lymphoma, Leukemia, Meningeal Neoplasm, and Brain and Central Nervous System Tumors.

CAS Number88859-04-5
PubChem CID76968809
IUPAC Name2-[[(2S,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-yl]sulfanyl]ethanesulfonic acid
Molecular FormulaC9H19Cl2N2O5PS2
Molecular Weight401.3
XLogP0.4
Topological Polar Surface Area130
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count21
Formal Charge0
Complexity456
SMILES
C1CO[P@@](=O)(N[C@H]1SCCS(=O)(=O)O)N(CCCl)CCCl
InChI
InChI=1S/C9H19Cl2N2O5PS2/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17/h9H,1-8H2,(H,12,14)(H,15,16,17)/t9-,19-/m0/s1
InChIKey
PBUUPFTVAPUWDE-UGZDLDLSSA-N
Chemical Structure
2D Structure
2D structure of Mafosfamide
CAS: 88859-04-5
CID: 76968809
Formula: C9H19Cl2N2O5PS2
MW: 401.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.3
XLogP30.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass399.9850064
Monoisotopic Mass399.9850064
Topological Polar Surface Area130 Ų
Heavy Atom Count21
Formal Charge0
Complexity456
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T68434-01Mafosfamide
FM182718-01Mafosfamide sodium
sc-211761AMafosfamide Sodium Salt

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