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CK0106023

CAT: 0013-GTR19210968-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210968-03Size:100 mg
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Description
CK0106023 is a specific Kinesin Spindle Protein (KSP) inhibitor. In both in vitro cellular assays and in vivo tumor-bearing mouse models, it induces characteristic monopolar mitotic spindles and demonstrates antitumor efficacy comparable to paclitaxel. Its expression profile, being high in proliferating tissues but absent in postmitotic neurons, makes it a research tool for studying mitosis and cancer.
CAS Number
336115-72-1
Field of Research
Signal Transduction
Smiles
C (N (C (=O) C1=CC=C (Br) C=C1) CCCN (C) C) (CC) C=2N (CC3=CC=CC=C3) C (=O) C=4C (N2) =CC (Cl) =CC4
Molecular Formula
C30H32BrClN4O2
Molecular Weight
595.96
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Benzamide, 4-bromo-N-(1-(7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl)propyl)-N-(3-(dimethylamino)propyl)-
CAS Number336115-72-1
PubChem CID11261882
IUPAC NameN-[1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)propyl]-4-bromo-N-[3-(dimethylamino)propyl]benzamide
Molecular FormulaC30H32BrClN4O2
Molecular Weight596.0
XLogP6.2
Topological Polar Surface Area56.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count10
Heavy Atom Count38
Formal Charge0
Complexity825
SMILES
CCC(C1=NC2=C(C=CC(=C2)Cl)C(=O)N1CC3=CC=CC=C3)N(CCCN(C)C)C(=O)C4=CC=C(C=C4)Br
InChI
InChI=1S/C30H32BrClN4O2/c1-4-27(35(18-8-17-34(2)3)29(37)22-11-13-23(31)14-12-22)28-33-26-19-24(32)15-16-25(26)30(38)36(28)20-21-9-6-5-7-10-21/h5-7,9-16,19,27H,4,8,17-18,20H2,1-3H3
InChIKey
PZVLDHUUSWUATQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Benzamide, 4-bromo-N-(1-(7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl)propyl)-N-(3-(dimethylamino)propyl)-
CAS: 336115-72-1
CID: 11261882
Formula: C30H32BrClN4O2
MW: 596.0
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight596.0
XLogP36.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count10
Exact Mass594.13972
Monoisotopic Mass594.13972
Topological Polar Surface Area56.2 Ų
Heavy Atom Count38
Formal Charge0
Complexity825
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T69415-01CK0106023

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