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AA43279

CAT: 0013-GTR19208696-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208696-01Size:5 mg
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Description
AA43279 is a novel, selective Nav1.1 activator that enhances the excitability of parvalbumin-positive interneurons, thereby elevating inhibitory synaptic transmission onto pyramidal neurons. This tool compound is useful for investigating circuit dynamics, neurodevelopmental disorders like Dravet Syndrome, and the role of interneuron dysfunction in both in vitro and in vivo epilepsy models.
CAS Number
354812-16-1
Field of Research
Pharmacology & Drug Discovery
Smiles
COc1ccc (cc1) -c1cc (N) c (s1) C (N) =O
Molecular Formula
C12H12N2O2S
Molecular Weight
248.3
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide

3-amino-5-(4-methoxyphenyl)-2-thiophenecarboxamide is a member of the class of thiophenes that is thiophene substituted by aminocarbonyl, amino, and 4-methoxyphenyl groups at positions 2, 3, and 5, respectively. It is a small-molecule activator of Nav 1.1 channels. It has a role as an anticonvulsant and a sodium channel modulator. It is a primary carboxamide, a monomethoxybenzene, a member of thiophenes and an aromatic amine.

CAS Number354812-16-1
PubChem CID4278270
IUPAC Name3-amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
Molecular FormulaC12H12N2O2S
Molecular Weight248.30
XLogP2.3
Topological Polar Surface Area107
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity280
SMILES
COC1=CC=C(C=C1)C2=CC(=C(S2)C(=O)N)N
InChI
InChI=1S/C12H12N2O2S/c1-16-8-4-2-7(3-5-8)10-6-9(13)11(17-10)12(14)15/h2-6H,13H2,1H3,(H2,14,15)
InChIKey
OEUITKOCUWEFOB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
CAS: 354812-16-1
CID: 4278270
Formula: C12H12N2O2S
MW: 248.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight248.30
XLogP32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass248.06194880
Monoisotopic Mass248.06194880
Topological Polar Surface Area107 Ų
Heavy Atom Count17
Formal Charge0
Complexity280
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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