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AA43279

CAT: 0498-bs-82687C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82687C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 µM) . In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1
Conjugation
Unconjugated
Buffer
Tan solid
Storage Conditions
-20°C

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CatalogName
OR1075594AA43279

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