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AA43279

CAT: 0931-T71854-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T71854-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
354812-16-1
Target
Others, Sodium Channel
Related Pathways
Membrane transporter/Ion channel, Others
Bioactivity
AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons.
Smiles
COc1ccc(cc1)-c1cc(N)c(s1)C(N)=O
Molecular Formula
C12H12N2O2S
Molecular Weight
248.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide

3-amino-5-(4-methoxyphenyl)-2-thiophenecarboxamide is a member of the class of thiophenes that is thiophene substituted by aminocarbonyl, amino, and 4-methoxyphenyl groups at positions 2, 3, and 5, respectively. It is a small-molecule activator of Nav 1.1 channels. It has a role as an anticonvulsant and a sodium channel modulator. It is a primary carboxamide, a monomethoxybenzene, a member of thiophenes and an aromatic amine.

CAS Number354812-16-1
PubChem CID4278270
IUPAC Name3-amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
Molecular FormulaC12H12N2O2S
Molecular Weight248.30
XLogP2.3
Topological Polar Surface Area107
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity280
SMILES
COC1=CC=C(C=C1)C2=CC(=C(S2)C(=O)N)N
InChI
InChI=1S/C12H12N2O2S/c1-16-8-4-2-7(3-5-8)10-6-9(13)11(17-10)12(14)15/h2-6H,13H2,1H3,(H2,14,15)
InChIKey
OEUITKOCUWEFOB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
CAS: 354812-16-1
CID: 4278270
Formula: C12H12N2O2S
MW: 248.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight248.30
XLogP32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass248.06194880
Monoisotopic Mass248.06194880
Topological Polar Surface Area107 Ų
Heavy Atom Count17
Formal Charge0
Complexity280
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
463535AA43279

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