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AM-9635

CAT: 0013-GTR19208452-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208452-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM-9635 is a potent and selective PI3Kδ inhibitor with strong cellular activity, as evidenced by its in vitro pAKT IC50 of 4.2 nM. In vivo, it demonstrates dose-dependent inhibition of KLH-specific IgG and IgM antibody responses, supporting its research application in immunology and B-cell mediated disease models.
CAS Number
1338483-10-5
Field of Research
Signal Transduction
Smiles
[C@H] (NC=1C (C#N) =C (N) N=CN1) (C) C=2N (C=3C (N2) =CC=C (F) C3) C=4C=C (F) C=NC4
Molecular Formula
C19H14F2N8
Molecular Weight
392.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(S)-4-Amino-6-((1-(6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile
CAS Number1338483-10-5
PubChem CID58459115
IUPAC Name4-amino-6-[[(1S)-1-[6-fluoro-1-(5-fluoro-3-pyridinyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Molecular FormulaC19H14F2N8
Molecular Weight392.4
XLogP2.7
Topological Polar Surface Area118
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity614
SMILES
C[C@@H](C1=NC2=C(N1C3=CC(=CN=C3)F)C=C(C=C2)F)NC4=NC=NC(=C4C#N)N
InChI
InChI=1S/C19H14F2N8/c1-10(27-18-14(6-22)17(23)25-9-26-18)19-28-15-3-2-11(20)5-16(15)29(19)13-4-12(21)7-24-8-13/h2-5,7-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
InChIKey
QLWGSXWLXIBFPF-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of (S)-4-Amino-6-((1-(6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile
CAS: 1338483-10-5
CID: 58459115
Formula: C19H14F2N8
MW: 392.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight392.4
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass392.13094880
Monoisotopic Mass392.13094880
Topological Polar Surface Area118 Ų
Heavy Atom Count29
Formal Charge0
Complexity614
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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