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AZD-8418

CAT: 0013-GTR19208119-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208119-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD8418 and AZD8529 are positive allosteric modulators of the mGlu2 receptor, demonstrating efficacy in reducing nicotine self-administration and seeking in preclinical models. Their selective inhibition of nicotine- versus food-maintained behavior, along with effects on cue-induced reinstatement, supports research into glutamate modulation for substance use disorders.
CAS Number
1198309-73-7
Smiles
O=C1C=2C (CN1[C@@H] (C) C3CC3) =CC (=CC2Cl) C4=CC (C (N (C) C) =O) =NO4
Molecular Formula
C19H20ClN3O3
Molecular Weight
373.83
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Azd-8418

Azd8418 is under investigation in clinical trial NCT01027234 (This Study Will Assess the Safety and Tolerability of AZD8418 After Single Increasing Oral Doses).

CAS Number1198309-73-7
PubChem CID44556193
IUPAC Name5-[7-chloro-2-[(1S)-1-cyclopropylethyl]-1-oxo-3H-isoindol-5-yl]-N,N-dimethyl-1,2-oxazole-3-carboxamide
Molecular FormulaC19H20ClN3O3
Molecular Weight373.8
XLogP2.7
Topological Polar Surface Area66.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity582
SMILES
C[C@@H](C1CC1)N2CC3=C(C2=O)C(=CC(=C3)C4=CC(=NO4)C(=O)N(C)C)Cl
InChI
InChI=1S/C19H20ClN3O3/c1-10(11-4-5-11)23-9-13-6-12(7-14(20)17(13)19(23)25)16-8-15(21-26-16)18(24)22(2)3/h6-8,10-11H,4-5,9H2,1-3H3/t10-/m0/s1
InChIKey
MCPBSUCAISQZQK-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of Azd-8418
CAS: 1198309-73-7
CID: 44556193
Formula: C19H20ClN3O3
MW: 373.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight373.8
XLogP32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass373.1193192
Monoisotopic Mass373.1193192
Topological Polar Surface Area66.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity582
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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