ATX inhibitor 5

CAT: 0013-GTR19206537-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19206537-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

ATX inhibitor 5 is a potent, orally bioavailable small molecule targeting autotaxin with an IC50 of 15.3 nM. It has demonstrated anti-fibrotic efficacy in a CCl4-induced mouse model of hepatic fibrosis, making it a valuable research tool for studying ATX biology and liver disease pathogenesis.

CAS Number

2402772-45-4

Product Name Alternative

Autotaxin, ATX inhibitor 5, ATX

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Purity

98.77% (May vary between batches)

Solubility

DMSO:225 mg/mL (473.81 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.95 mM)

Smiles

FC (F) (F) c1cccc (Nc2ncnc3CCN (Cc23) C (=O) N\N=C\c2ccc (Cl) cc2) c1

Molecular Formula

C22H18ClF3N6O

Molecular Weight

474.87

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

ATX inhibitor 5

CAS Number	2402772-45-4
PubChem CID	146014477
IUPAC Name	N-[(E)-(4-chlorophenyl)methylideneamino]-4-[3-(trifluoromethyl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
Molecular Formula	C22H18ClF3N6O
Molecular Weight	474.9
XLogP	4.4
Topological Polar Surface Area	82.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	33
Formal Charge	0
Complexity	688

SMILES

C1CN(CC2=C1N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)C(=O)N/N=C/C4=CC=C(C=C4)Cl

InChI

InChI=1S/C22H18ClF3N6O/c23-16-6-4-14(5-7-16)11-29-31-21(33)32-9-8-19-18(12-32)20(28-13-27-19)30-17-3-1-2-15(10-17)22(24,25)26/h1-7,10-11,13H,8-9,12H2,(H,31,33)(H,27,28,30)/b29-11+

InChIKey

VHRNHTUEITYZIH-VPUKRXIYSA-N

Chemical Structure

2D Structure

CAS: 2402772-45-4

CID: 146014477

Formula: C22H18ClF3N6O

MW: 474.9

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	474.9
XLogP3	4.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	474.1182714
Monoisotopic Mass	474.1182714
Topological Polar Surface Area	82.5 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	688
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
GTR19186921-01	ATX inhibitor 15
GTR19185336-01	ATX inhibitor 9
GTR19185078-01	ATX inhibitor 22
GTR19185056-01	ATX inhibitor 12
GTR19185028-01	ATX inhibitor 8
GTR19184707-01	ATX inhibitor 19
GTR19184658-01	ATX inhibitor 11
GTR19258001-01	ATX inhibitor 26
GTR19185122-01	ATX inhibitor 10
GTR19184757-01	ATX inhibitor 16

Alternative Products

Catalog	Name
105-310	Ribunuclease Inhibitor / RNase Inhibitor
880001	Inhibitor A
TBI4861-5MG	GSK872, Necroptosis inhibitor / RIP3 inhibitor
TBI1188-5MG	Xanthohumol, VCP inhibitor / Autophagy inhibitor
TBI1528-25MG	JNK inhibitor IX, JNK inhibitor
TBI2616-25MG	Oridonin, HSP70 inhibitor; Inflammasome inhibitor
TBI2567-100UG	Herbimycin A, HSP90 inhibitor; Src inhibitor
217735-01	Rad6 Inhibitor (TZ9, HHR6 Inhibitor)
SF2784-5mg	AKT inhibitor VIII (Akt inhibitor)
TBI2877-200UG	Conglobatin, NFAT inhibitor; HSP90 inhibitor

ATX inhibitor 5

Chemical Information

Related Products

Alternative Products

Popular Products