Galidesivir

CAT: 0013-GTR19206471-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19206471-01Size:1 mg

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Description

Galidesivir (BCX4430) is a broad-spectrum adenosine analog antiviral that functions by inhibiting viral RNA-dependent RNA polymerase. It has demonstrated in vitro activity against numerous RNA viruses and has shown efficacy in reducing lung infection in animal models, supporting its research in virology and infectious disease.

CAS Number

249503-25-1

Product Name Alternative

BCX 4430, BCX4430, BCX-4430, Antiviral, DNASynthesis, DNA Synthesis, Immucillin-A, Galidesivir, RNA Synthesis, RNA polymerase, RNASynthesis, RdRp

Field of Research

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology

Purity

96.73% (May vary between batches)

Solubility

H2O:50 mg/mL (188.49 mM)

Smiles

Nc1ncnc2c (c[nH]c12) [C@@H]1N[C@H] (CO) [C@@H] (O) [C@H]1O

Molecular Formula

C11H15N5O3

Molecular Weight

265.27

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Galidesivir

Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various pathogens, including Ebola, Marburg, Yellow Fever and Zika viruses. In vitro, it displayed broad-spectrum antiviral activity against various negative- and positive-sense RNA viruses, including coronaviruses, filoviruses, and arenaviruses. Phase 1 clinical trials have begun to determine the safety of this drug in humans. Because of its activity against other coronaviruses, it may be studied as a potential therapy for COVID-19.

CAS Number	249503-25-1
PubChem CID	10445549
IUPAC Name	(2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
Molecular Formula	C11H15N5O3
Molecular Weight	265.27
XLogP	-2.1
Topological Polar Surface Area	140
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Heavy Atom Count	19
Formal Charge	0
Complexity	333

SMILES

C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O

InChI

InChI=1S/C11H15N5O3/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15)/t5-,7+,9-,10+/m1/s1

InChIKey

AMFDITJFBUXZQN-KUBHLMPHSA-N

Chemical Structure

2D Structure

CAS: 249503-25-1

CID: 10445549

Formula: C11H15N5O3

MW: 265.27

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	265.27
XLogP3	-2.1
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	265.11748936
Monoisotopic Mass	265.11748936
Topological Polar Surface Area	140 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	333
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
OR1039243	Galidesivir
T41177	Galidesivir dihydrochloride
HY-18649B	Galidesivir (dihydrochloride)
AR-G02006-01	Galidesivir Triphosphate
AR-G02007-01	Galidesivir-13C5
T10491L-01	Galidesivir hydrochloride
HY-18649-01	Galidesivir (hydrochloride)
328059	Galidesivir 2HCl
AR-G02008-01	Galidesivir DiHCl
A20930-100	Galidesivir hydrochloride 100mg

Galidesivir

Chemical Information

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