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Galidesivir

CAT: 0931-T10491-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T10491-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
249503-25-1
Target
DNA/RNA Synthesis, Antiviral, SARS-CoV, Virus Protease
Related Pathways
Microbiology/Virology, DNA Damage/DNA Repair, Immunology/Inflammation, Cell Cycle/Checkpoint
Purity
0.9913
Bioactivity
Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and reduces lung infections in infected animals.
Smiles
Nc1ncnc2c(c[nH]c12)[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O
Molecular Formula
C11H15N5O3
Molecular Weight
265.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Galidesivir

Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various pathogens, including Ebola, Marburg, Yellow Fever and Zika viruses. In vitro, it displayed broad-spectrum antiviral activity against various negative- and positive-sense RNA viruses, including coronaviruses, filoviruses, and arenaviruses. Phase 1 clinical trials have begun to determine the safety of this drug in humans. Because of its activity against other coronaviruses, it may be studied as a potential therapy for COVID-19.

CAS Number249503-25-1
PubChem CID10445549
IUPAC Name(2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
Molecular FormulaC11H15N5O3
Molecular Weight265.27
XLogP-2.1
Topological Polar Surface Area140
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity333
SMILES
C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
InChI
InChI=1S/C11H15N5O3/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15)/t5-,7+,9-,10+/m1/s1
InChIKey
AMFDITJFBUXZQN-KUBHLMPHSA-N
Chemical Structure
2D Structure
2D structure of Galidesivir
CAS: 249503-25-1
CID: 10445549
Formula: C11H15N5O3
MW: 265.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight265.27
XLogP3-2.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass265.11748936
Monoisotopic Mass265.11748936
Topological Polar Surface Area140 Ų
Heavy Atom Count19
Formal Charge0
Complexity333
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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OR1039243Galidesivir
HY-18649BGalidesivir (dihydrochloride)
AR-G02006-01Galidesivir Triphosphate
GTR19188530Galidesivir dihydrochloride
AR-G02007-01Galidesivir-13C5
HY-18649-01Galidesivir (hydrochloride)
328059Galidesivir 2HCl
MBS5752785Galidesivir hydrochloride
AR-G02008-01Galidesivir DiHCl
A20930-100Galidesivir hydrochloride 100mg

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