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GDC-0276

CAT: 0013-GTR19205806-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19205806-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GDC-0276 is a potent and selective oral inhibitor of the voltage-gated sodium channel NaV1.7. It serves as a valuable research tool for investigating pain pathways and has demonstrated efficacy in preclinical models of neuropathic and inflammatory pain.
CAS Number
1494581-70-2
Product Name Alternative
GDC0276, GDC-0276, GDC 0276, NaV1.7 Electrophysiology, RG7893, RG-7893
Field of Research
Pharmacology & Drug Discovery
Purity
98.94% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:5 mg/mL (10.81 mM) ; DMSO:100 mg/mL (216.18 mM)
Smiles
O=C (NS (=O) (=O) N1CCC1) C=2C=C (C (OCC34CC5CC (CC (C5) C3) C4) =CC2F) C6CC6
Molecular Formula
C24H31FN2O4S
Molecular Weight
462.58
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gdc-0276

NaV1.7 Inhibitor

CAS Number1494581-70-2
PubChem CID91809347
IUPAC Name4-(1-adamantylmethoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamide
Molecular FormulaC24H31FN2O4S
Molecular Weight462.6
XLogP4.7
Topological Polar Surface Area84.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity809
SMILES
C1CN(C1)S(=O)(=O)NC(=O)C2=C(C=C(C(=C2)C3CC3)OCC45CC6CC(C4)CC(C6)C5)F
InChI
InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)
InChIKey
PTCBNPULJWGSML-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gdc-0276
CAS: 1494581-70-2
CID: 91809347
Formula: C24H31FN2O4S
MW: 462.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight462.6
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass462.19885681
Monoisotopic Mass462.19885681
Topological Polar Surface Area84.1 Ų
Heavy Atom Count32
Formal Charge0
Complexity809
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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