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GDC-0879

CAT: 0013-GTR19160841-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160841-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line; shows expected activity only against C-Raf against a panel of 140 kinases at 1 uM; shows comparable potency in A375 melanoma and Colo205 colorectal carcinoma cell lines with IC50 of 59 nM and 29 nM for pMEK1 inhibition respectively; shows tumor growth inhibition in A375 xenografts; orally active.Skin Cancer Preclinical.
CAS Number
905281-76-7
Product Name Alternative
GDC0879 | GDC 0879
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OCCN1N=C (C2=CC=NC=C2) C (C3=CC4=C (/C (CC4) =N/O) C=C3) =C1
Molecular Formula
C19H18N4O2
Molecular Weight
334.3718
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Inden-1-one, 2,3-dihydro-5-[1- (2-hydroxyethyl) -3- (4-pyridinyl) -1H-pyrazol-4-yl]-, oxime

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A5071-5.1GDC-0879
451116-01GDC 0879

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