Ephrin-A1

CAT: 0209-103-M375Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-103-M375Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EphrinA1, also known as B61, LERK1, and EFL1, is a member of the Ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The A-class ligands have a GPI anchor following the conserved sequence. EphrinA1 binds EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. The extracellular domains of human and mouse EphrinA1 share 85% amino acid identity. Only membranebound or Fc -clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation. In vivo, the ligands and receptors display reciprocal expression. Nearly all receptors and ligands are expressed in developing and adult neural tissue. The Eph/Ephrin families also appear to play a role in angiogenesis.
Synonyms
Efna1; B61; Efl1; Epl1; Eplg1; Lerk1; AI325262
NCBI Gene ID
13636
UniProt
P52793
Accession Number
NP_034237.3
Accession Number mRNA
NM_010107.4
Chromosomal Location
3 F1; 3 48.5 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse protein Ephrin-A1
Clone
(#6D31)
Applications
WB
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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