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VHL Ligand 8

CAT: 0013-GTR19204161Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204161Size:100 mg
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Description
VHL Ligand 8 is a key component for synthesizing the potent PROTAC degrader ARD-266. It serves as a high-affinity ligand for the VHL E3 ligase, enabling the targeted degradation of the androgen receptor (AR) in prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1 with DC50 values as low as 0.2 nM. This tool compound is valuable for researching AR-dependent cancers and PROTAC mechanism of action in vitro.
CAS Number
2701565-76-4
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C ([C@H] (C (C) C) C=1ON=C (C) C1) (=O) N2[C@H] (C (N[C@@H] (CC (O) =O) C3=CC=CC=C3) =O) C[C@@H] (O) C2
Molecular Formula
C23H29N3O6
Molecular Weight
443.49
Storage Conditions
-20°C
Notes
For research use only.

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