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AGI-24512

CAT: 0013-GTR19204087-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204087-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGI-24512 is a potent and selective MAT2A inhibitor (IC50: 8 nM) with antiproliferative effects in MTAP-deficient cancer cells. Its mechanism, which induces DNA damage, supports its use in both in vitro and in vivo studies exploring novel combination therapies for oncology research.
CAS Number
2201066-53-5
Product Name Alternative
S-adenosylmethionine Synthetase, PRMT5, HCT116, MAT2A, MATA2, MTAP, methylthioadenosine phosphorylase, Methionine Adenosyltransferase (MAT), anticancer, antiproliferative, AGI 24512, AGI24512, AGI-24512, DNA damage response, DNA
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
98.55% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM) ; DMSO:80 mg/mL (199.77 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
Cc1[nH]c2c (N3CCCCC3) c (nn2c (=O) c1-c1ccc (O) cc1) -c1ccccc1
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS Number2201066-53-5
PubChem CID134307780
IUPAC Name6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-piperidin-1-yl-1H-pyrazolo[1,5-a]pyrimidin-7-one
Molecular FormulaC24H24N4O2
Molecular Weight400.5
XLogP4.1
Topological Polar Surface Area68.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity779
SMILES
CC1=C(C(=O)N2C(=N1)C(=C(N2)C3=CC=CC=C3)N4CCCCC4)C5=CC=C(C=C5)O
InChI
InChI=1S/C24H24N4O2/c1-16-20(17-10-12-19(29)13-11-17)24(30)28-23(25-16)22(27-14-6-3-7-15-27)21(26-28)18-8-4-2-5-9-18/h2,4-5,8-13,26,29H,3,6-7,14-15H2,1H3
InChIKey
VFEXODVWKUOZBF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS: 2201066-53-5
CID: 134307780
Formula: C24H24N4O2
MW: 400.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight400.5
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass400.18992602
Monoisotopic Mass400.18992602
Topological Polar Surface Area68.2 Ų
Heavy Atom Count30
Formal Charge0
Complexity779
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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