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BMS-906024

CAT: 0013-GTR19203904-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203904-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-906024 (Osugacestat) is a potent, orally bioavailable γ-secretase inhibitor that blocks signaling from all four Notch receptors (Notch1-4) . It demonstrates broad-spectrum antitumor activity in human cancer xenograft models, supporting its investigation in oncology research for both in vitro and in vivo studies.
CAS Number
1401066-79-2
Product Name Alternative
Osugacestat, Notch2, Notch4, Notch3, Notch, Notch1, Gammasecretase, AL-101, BMS 906024, BMS906024, BMS-906024, BM-0018, γ secretase
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
99.87% (May vary between batches)
Solubility
DMSO:5 mg/mL (8.98 mM)
Smiles
CN1c2ccccc2C (=N[C@H] (NC (=O) [C@H] (CCC (F) (F) F) [C@H] (CCC (F) (F) F) C (N) =O) C1=O) c1ccccc1
Molecular Formula
C26H26F6N4O3
Molecular Weight
556.5
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Bms 906024

(2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide is a primary carboxamide, a secondary carboxamide and a tertiary carboxamide.

CAS Number1401066-79-2
PubChem CID66550890
IUPAC Name(2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide
Molecular FormulaC26H26F6N4O3
Molecular Weight556.5
XLogP4.5
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Heavy Atom Count39
Formal Charge0
Complexity916
SMILES
CN1C2=CC=CC=C2C(=N[C@@H](C1=O)NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(=O)N)C3=CC=CC=C3
InChI
InChI=1S/C26H26F6N4O3/c1-36-19-10-6-5-9-18(19)20(15-7-3-2-4-8-15)34-22(24(36)39)35-23(38)17(12-14-26(30,31)32)16(21(33)37)11-13-25(27,28)29/h2-10,16-17,22H,11-14H2,1H3,(H2,33,37)(H,35,38)/t16-,17+,22+/m0/s1
InChIKey
AYOUDDAETNMCBW-GSHUGGBRSA-N
Chemical Structure
2D Structure
2D structure of Bms 906024
CAS: 1401066-79-2
CID: 66550890
Formula: C26H26F6N4O3
MW: 556.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight556.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass556.19090968
Monoisotopic Mass556.19090968
Topological Polar Surface Area105 Ų
Heavy Atom Count39
Formal Charge0
Complexity916
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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