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JAK1-IN-4

CAT: 0013-GTR19203742-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203742-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK1-IN-4 is a potent and selective JAK1 inhibitor, demonstrating an IC50 of 85 nM for JAK1 with significant selectivity over JAK2 and JAK3. It effectively suppresses STAT3 phosphorylation in cellular assays, such as in NCI-H1975 cells (IC50 = 227 nM), making it a useful research tool for studying JAK-STAT signaling in oncology and immunology research.
CAS Number
2091134-35-7
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N (C ([C@@H] (C) N1C[C@@H] (C) N (C) CC1) =O) C2=C3C (C (=CN3) C4=NC (NC=5C (OC) =NN (C) C5) =NC=C4F) =CC=C2
Molecular Formula
C26H32FN9O2
Molecular Weight
521.59
Storage Conditions
-20°C
Notes
For research use only.

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