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CLZ-8

CAT: 0013-GTR19203571-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19203571-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CLZ-8 (Mcl1-IN-8) is an orally bioavailable, radioprotective small molecule that inhibits the Mcl-1/PUMA interaction. It mitigates radiation-induced apoptosis and cellular damage in HUVECs in vitro by suppressing PUMA overexpression, showing potential for research in radiation biology and apoptosis signaling pathways.
CAS Number
678158-55-9
Product Name Alternative
CLZ 8, CLZ8, Mcl-1, Mcl1 IN 8, Mcl1IN8, Mcl-1-IN-8, Mcl1-IN-8
Field of Research
Cell Biology
Purity
99.85% (May vary between batches)
Solubility
DMSO:40 mg/mL (101.65 mM) ;10% DMSO+90% Corn Oil:1 mg/mL (2.54 mM)
Smiles
OCCN1CCN (CC1) C1=NC (=O) \C (S1) =C\c1ccc (cc1) -c1ccccc1
Molecular Formula
C22H23N3O2S
Molecular Weight
393.5
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mcl1-IN-8
CAS Number678158-55-9
PubChem CID988971
IUPAC Name(5Z)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-[(4-phenylphenyl)methylidene]-1,3-thiazol-4-one
Molecular FormulaC22H23N3O2S
Molecular Weight393.5
XLogP3.2
Topological Polar Surface Area81.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity599
SMILES
C1CN(CCN1CCO)C2=NC(=O)/C(=C/C3=CC=C(C=C3)C4=CC=CC=C4)/S2
InChI
InChI=1S/C22H23N3O2S/c26-15-14-24-10-12-25(13-11-24)22-23-21(27)20(28-22)16-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-9,16,26H,10-15H2/b20-16-
InChIKey
IBEWMFVUBLAYJT-SILNSSARSA-N
Chemical Structure
2D Structure
2D structure of Mcl1-IN-8
CAS: 678158-55-9
CID: 988971
Formula: C22H23N3O2S
MW: 393.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight393.5
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass393.15109816
Monoisotopic Mass393.15109816
Topological Polar Surface Area81.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity599
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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