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MRT00033659

CAT: 0013-GTR19204224-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204224-01Size:2 mg
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Description
MRT00033659 is a pyrazolo-pyridine analogue functioning as a potent, broad-spectrum kinase inhibitor, notably targeting CK1δ (IC50=0.9 μM) and CHK1 (IC50=0.23 μM) . Its mechanism induces p53 pathway activation and E2F-1 destabilization, supporting its application in cancer research for in vitro studies of cell cycle regulation and DNA damage response pathways.
CAS Number
1401731-54-1
Field of Research
Cell Biology, Metabolism Research, Stem Cell & Developmental Biology
Smiles
CC (=O) Nc1cccc (c1) -c1cnc2[nH]nc (C) c2c1
Molecular Formula
C15H14N4O
Molecular Weight
266.3
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)acetamide
CAS Number1401731-54-1
PubChem CID66555775
IUPAC NameN-[3-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)phenyl]acetamide
Molecular FormulaC15H14N4O
Molecular Weight266.30
XLogP2
Topological Polar Surface Area70.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity362
SMILES
CC1=C2C=C(C=NC2=NN1)C3=CC(=CC=C3)NC(=O)C
InChI
InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
InChIKey
YFBPGSDPFRCNOY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)acetamide
CAS: 1401731-54-1
CID: 66555775
Formula: C15H14N4O
MW: 266.30
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight266.30
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass266.11676108
Monoisotopic Mass266.11676108
Topological Polar Surface Area70.7 Ų
Heavy Atom Count20
Formal Charge0
Complexity362
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T16141-01MRT00033659

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