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MRT00033659

CAT: 0931-T16141-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T16141-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1401731-54-1
Target
Others, MDM-2/p53, Chk, Early 2 Factor (E2F), Casein Kinase
Related Pathways
Metabolism, Cell Cycle/Checkpoint, Apoptosis, Stem Cells, Others
Bioactivity
MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM) . MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
Smiles
CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Molecular Formula
C15H14N4O
Molecular Weight
266.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-(3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)acetamide
CAS Number1401731-54-1
PubChem CID66555775
IUPAC NameN-[3-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)phenyl]acetamide
Molecular FormulaC15H14N4O
Molecular Weight266.30
XLogP2
Topological Polar Surface Area70.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity362
SMILES
CC1=C2C=C(C=NC2=NN1)C3=CC(=CC=C3)NC(=O)C
InChI
InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
InChIKey
YFBPGSDPFRCNOY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)acetamide
CAS: 1401731-54-1
CID: 66555775
Formula: C15H14N4O
MW: 266.30
Interactive 3D Structure
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Computed Properties
PropertyValue
Molecular Weight266.30
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass266.11676108
Monoisotopic Mass266.11676108
Topological Polar Surface Area70.7 Ų
Heavy Atom Count20
Formal Charge0
Complexity362
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-117857-01MRT00033659

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