DS-437

CAT: 0013-GTR19203402Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19203402Size:2 mg

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Description

DS-437 is a dual inhibitor of PRMT5 and PRMT7 (IC50: 6 μM), and also inhibits DNMT3A and DNMT3B at higher concentrations. It suppresses FOXP3 methylation and is used in vitro to study epigenetic regulation in immunology and oncology research.

CAS Number

1674364-87-4

Field of Research

Epigenetics & Chromatin

Smiles

CCNC (=O) NCCSC[C@H]1O[C@H] ([C@H] (O) [C@@H]1O) n1cnc2c (N) ncnc12

Molecular Formula

C15H23N7O4S

Molecular Weight

397.45

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-

CAS Number	1674364-87-4
PubChem CID	122178085
IUPAC Name	1-[2-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea
Molecular Formula	C15H23N7O4S
Molecular Weight	397.5
XLogP	-0.8
Topological Polar Surface Area	186
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Heavy Atom Count	27
Formal Charge	0
Complexity	505

SMILES

CCNC(=O)NCCSC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O

InChI

InChI=1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10-,11-,14-/m1/s1

InChIKey

CACMCLIHCDTJHL-IDTAVKCVSA-N

Chemical Structure

2D Structure

CAS: 1674364-87-4

CID: 122178085

Formula: C15H23N7O4S

MW: 397.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	397.5
XLogP3	-0.8
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	397.15322341
Monoisotopic Mass	397.15322341
Topological Polar Surface Area	186 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	505
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19197736-01	DS-8587
GTR19257745-01	DS-1150b
GTR19238269-01	DS-1093a
GTR19171094-01	DS-7423
GTR19167436-01	DS-1001b
GTR19165783-01	DS-1205

Alternative Products

Catalog	Name
MBS3602556	DS-437
A24360-5	DS-437 5mg
A24360-50	DS-437 50mg
A24360-10	DS-437 10mg
A24360-100	DS-437 100mg
MBS3603492-01	KNK-437
BA7172-1	HFI-437
B6785-5.1	CD 437

DS-437

Chemical Information

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