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SB-218078

CAT: 0013-GTR19203123Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203123Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-218078 is a potent, ATP-competitive, and cell-permeable inhibitor of checkpoint kinase 1 (Chk1), inhibiting cdc25C phosphorylation with an IC50 of 15 nM. It shows weaker activity against Cdc2 and PKC. This inhibitor is widely used in vitro to study DNA damage response, cell cycle checkpoint mechanisms, and as a potential chemosensitizer in cancer research.
CAS Number
135897-06-2
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Smiles
O=C1NC (=O) c2c1c1c3ccccc3n3C4CCC (O4) n4c5ccccc5c2c4c13
Molecular Formula
C24H15N3O3
Molecular Weight
393.39
Storage Conditions
-20°C
Notes
For research use only.

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