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SB-756050

CAT: 0013-GTR19160328-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160328-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-756050 is a G protein-coupled bile acid receptor 1 (GPBAR1) agonist potentially for the treatment of type 2 diabetes. (In Vivo) :SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different.
CAS Number
447410-57-3
Product Name Alternative
SB-756050 | SB 756050 | SB756050
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 150 mg/mL; 299.65 mM
Smiles
O=S (=O) (N1CCN (S (=O) (=O) c2ccc (OC) c (OC) c2) CCC1) c1ccc (OC) c (OC) c1
Molecular Formula
C21H28N2O8S2
Molecular Weight
500.59
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,4-bis ((3,4-dimethoxyphenyl) sulfonyl) -1,4-diazepane

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