SB-218078

• Target :

  PKC|||Apoptosis|||Chk|||CDK

• Related Pathways :

  Chromatin/Epigenetic|||Apoptosis|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling

• Bioactivity :

  SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM) . SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM) .

• Smiles :

  O=C1NC(=O)c2c1c1c3ccccc3n3C4CCC(O4)n4c5ccccc5c2c4c13

• Molecular Formula :

  C24H15N3O3

• Molecular Weight :

  393.39

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  135897-06-2