Sarcosine-d3

Sarcosine-d3

• CAS Number: 118685-91-9
• UNSPSC Description: Sarcosine-d3 is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
• Target Antigen: Endogenous Metabolite; GlyT; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Purity: 98.0
• Solubility: H2O : 125 mg/mL (ultrasonic)
• Smiles: O=C(O)CNC([2H])([2H])[2H]
• Molecular Weight: 92.11
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7.|[3]Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported