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Flecainide

CAT: 0013-GTR19201745-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19201745-01Size:5 mg
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Description
Flecainide is a small molecule antiarrhythmic agent that functions as a sodium channel blocker and IKr inhibitor. It is used in research for studying paroxysmal supraventricular tachycardia (PSVT) mechanisms and is applied in both in vitro electrophysiology assays and in vivo cardiac arrhythmia models.
CAS Number
54143-55-4
Product Name Alternative
Apocard
Field of Research
Pharmacology & Drug Discovery
Purity
99.89% (May vary between batches)
Solubility
DMSO:80 mg/mL (193.08 mM) ; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.96 mM)
Smiles
FC (F) (F) COc1ccc (OCC (F) (F) F) c (c1) C (=O) NCC1CCCCN1
Molecular Formula
C17H20F6N2O3
Molecular Weight
414.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Flecainide

Flecainide is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). It has a role as an anti-arrhythmia drug. It is a member of piperidines, a monocarboxylic acid amide, an aromatic ether and an organofluorine compound. It is a conjugate base of a flecainide(1+).

CAS Number54143-55-4
PubChem CID3356
IUPAC NameN-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Molecular FormulaC17H20F6N2O3
Molecular Weight414.34
XLogP3.8
Topological Polar Surface Area59.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity500
SMILES
C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F
InChI
InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)
InChIKey
DJBNUMBKLMJRSA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Flecainide
CAS: 54143-55-4
CID: 3356
Formula: C17H20F6N2O3
MW: 414.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight414.34
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass414.13781148
Monoisotopic Mass414.13781148
Topological Polar Surface Area59.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M14935-01Flecainide
326768Flecainide acetate
HY-W010950R-01Flecainide (Standard)
HY-W010950A-01Flecainide (hydrochloride)
276544-01Rac-Flecainide
TRC-F390003-1MGFlecainide-d4
M22227-01Flecainide hydrochloride

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