GP-82996

CAT: 0013-GTR19201642-06Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19201642-06Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GP-82996 (CINK4) is a selective CDK4/6 inhibitor with IC50 values of 1.5 μM (CDK4/cyclin D1) and 5.6 μM (CDK6/cyclin D1) . It induces apoptosis in U2OS osteosarcoma cells in vitro and serves as a valuable research tool for studying cell cycle dysregulation in cancer models.

CAS Number

359886-84-3

Product Name Alternative

CDK4/CyclinD1, Cdk4/6 Inhibitor IV, CDK6/cycD1, CINK 4, CINK4, CINK-4, GP 82996, GP82996, GP-82996

Field of Research

Cell Biology

Purity

99.57% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.38 mM) ; DMSO:50 mg/mL (109.51 mM)

Smiles

C (N1C=2C (=CC (NC=3N=C (N[C@@H]4CC[C@@H] (O) CC4) C=C (NCC) N3) =CC2) C=C1) C5=CC=CC=C5

Molecular Formula

C27H32N6O

Molecular Weight

456.58

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Cdk4/6 Inhibitor IV

4-[[6-(ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol is a member of indoles.

CAS Number	359886-84-3
PubChem CID	24825971
IUPAC Name	4-[[2-[(1-benzylindol-5-yl)amino]-6-(ethylamino)pyrimidin-4-yl]amino]cyclohexan-1-ol
Molecular Formula	C27H32N6O
Molecular Weight	456.6
XLogP	5.4
Topological Polar Surface Area	87
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Heavy Atom Count	34
Formal Charge	0
Complexity	608

SMILES

CCNC1=CC(=NC(=N1)NC2=CC3=C(C=C2)N(C=C3)CC4=CC=CC=C4)NC5CCC(CC5)O

InChI

InChI=1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)

InChIKey

YVXCDLCJCIDFHE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 359886-84-3

CID: 24825971

Formula: C27H32N6O

MW: 456.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	456.6
XLogP3	5.4
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	456.26375967
Monoisotopic Mass	456.26375967
Topological Polar Surface Area	87 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	608
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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