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M-Coumaric acid

CAT: 0804-HY-113357-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113357-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats[1][2][3].
CAS Number
588-30-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/m-Coumaric_acid.html
Purity
99.96
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C1=CC=CC(O)=C1
Molecular Formula
C9H8O3
Molecular Weight
164.16
Precautions
H315, H319, H335
References & Citations
[1]Ito H, et al. Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells. Biosci Biotechnol Biochem. 2008 Mar;72 (3) :885-8.|[2]Cabanes, J., et al., (1984) . Kinetic study on the slow inhibition of epidermis tyrosinase by m-coumaric acid. Biochimica et biophysica acta, 790 (2), 101–107. |[3]Moselhy Said Salama, et al., m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats. Journal of Pesticide Science. Online ISSN : 1349-0923. ISSN-L : 0385-1559.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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