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P-Coumaric acid

CAT: 0804-HY-N0351-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0351-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities[1][2][3][4].
CAS Number
501-98-4
Product Name Alternative
Trans-4-Hydroxycinnamic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p-Coumaric_acid.html
Purity
99.87
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)/C=C/C1=CC=C(O)C=C1
Molecular Formula
C9H8O3
Molecular Weight
164.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Hu X, et al. The Anti-tumor Effects of p-Coumaric Acid on Melanoma A375 and B16 Cells. Front Oncol. 2020 Oct 16;10:558414.|[2]NLou Z, et al. p-Coumaric acid kills bacteria through dual damage mechanisms. Food control, 2012, 25 (2) : 550-554..|[3]Sharma SH, et al. Protective effect of p-coumaric acid against 1,2 dimethylhydrazine induced colonic preneoplastic lesions in experimental rats. Biomed Pharmacother. 2017 Oct;94:577-588.|[4]Rafiee Z, et al Doxorubicin-Induced Nephrotoxicity Through Suppression of Oxidative Stress, Inflammation and Apoptosis. Arch Med Res. 2020 Jan;51 (1) :32-40.
Shipping Conditions
Room Temperature
Storage Conditions
RT, stored under nitrogen
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Microbial Metabolite

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