M-PEG10-acid

CAT: 0804-HY-140500-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-140500-01Size:25 mg

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Description

M-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

CAS Number

2409969-94-2

UNSPSC

12352203

Hazard Statement

H315, H319

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m-peg10-acid.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O

Molecular Formula

C22H44O12

Molecular Weight

500.58

Precautions

H315, H319

References & Citations

[1]John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Non-cleavable Linker; PEG Linkers

Chemical Information

m-PEG10-acid

CAS Number	2409969-94-2
PubChem CID	77078250
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Molecular Formula	C22H44O12
Molecular Weight	500.6
XLogP	-1.8
Topological Polar Surface Area	130
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	30
Heavy Atom Count	34
Formal Charge	0
Complexity	400

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

InChI

InChI=1S/C22H44O12/c1-25-4-5-27-8-9-29-12-13-31-16-17-33-20-21-34-19-18-32-15-14-30-11-10-28-7-6-26-3-2-22(23)24/h2-21H2,1H3,(H,23,24)

InChIKey

DWDMPMQTMMOYQC-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2409969-94-2

CID: 77078250

Formula: C22H44O12

MW: 500.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	500.6
XLogP3	-1.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	30
Exact Mass	500.28327683
Monoisotopic Mass	500.28327683
Topological Polar Surface Area	130 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	400
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19225496-01	M-PEG10-acid
T18119-01	M-PEG10-Br
T15837-01	M-PEG10-Tos
MBS5770984	m-PEG10-SH
572586	m-PEG10-azide
572473	m-PEG10-alcohol
T18120-01	m-PEG10-CH2COOH
T18118-01	M-PEG10-Boc
sc-152158	Peg10 siRNA (m)
571864	m-PEG10-amine

M-PEG10-acid

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