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M-PEG10-acid

CAT: 0804-HY-140500-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140500-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
CAS Number
2409969-94-2
UNSPSC
12352203
Hazard Statement
H315, H319
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-peg10-acid.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O
Molecular Formula
C22H44O12
Molecular Weight
500.58
Precautions
H315, H319
References & Citations
[1]John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

Chemical Information

m-PEG10-acid
CAS Number2409969-94-2
PubChem CID77078250
IUPAC Name3-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Molecular FormulaC22H44O12
Molecular Weight500.6
XLogP-1.8
Topological Polar Surface Area130
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count30
Heavy Atom Count34
Formal Charge0
Complexity400
SMILES
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI
InChI=1S/C22H44O12/c1-25-4-5-27-8-9-29-12-13-31-16-17-33-20-21-34-19-18-32-15-14-30-11-10-28-7-6-26-3-2-22(23)24/h2-21H2,1H3,(H,23,24)
InChIKey
DWDMPMQTMMOYQC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of m-PEG10-acid
CAS: 2409969-94-2
CID: 77078250
Formula: C22H44O12
MW: 500.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight500.6
XLogP3-1.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count30
Exact Mass500.28327683
Monoisotopic Mass500.28327683
Topological Polar Surface Area130 Ų
Heavy Atom Count34
Formal Charge0
Complexity400
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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