Products for Research Use Only
RegisterLogin

Tuvusertib

CAT: 0013-GTR19206540-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19206540-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ATR inhibitor 1
CAS Number
1613200-51-3
Product Name Alternative
Tuvusertib, ATM, Apoptosis, ATR, ATR inhibitor 1, Chk1, M 1774, M1774, M-1774
Field of Research
Cell Biology, Molecular Biology, Signal Transduction
Purity
98.44% (May vary between batches)
Solubility
DMSO:6.67 mg/mL (18.01 mM)
Smiles
Cn1cncc1-c1c (F) cncc1NC (=O) c1c (N) nn2cc (F) cnc12
Molecular Formula
C16H12F2N8O
Molecular Weight
370.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tuvusertib

Tuvusertib is an orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, tuvusertib selectively inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine protein kinase checkpoint kinase 1 (CHK1). This prevents ATR-mediated signaling, which results in the inhibition of DNA damage checkpoint activation, the disruption of DNA damage repair, and the induction of tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and survival. It is activated by DNA damage caused during DNA replication-associated stress.

CAS Number1613200-51-3
PubChem CID90199447
IUPAC Name2-amino-6-fluoro-N-[5-fluoro-4-(3-methylimidazol-4-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Molecular FormulaC16H12F2N8O
Molecular Weight370.32
XLogP0.2
Topological Polar Surface Area116
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity557
SMILES
CN1C=NC=C1C2=C(C=NC=C2NC(=O)C3=C4N=CC(=CN4N=C3N)F)F
InChI
InChI=1S/C16H12F2N8O/c1-25-7-21-5-11(25)12-9(18)3-20-4-10(12)23-16(27)13-14(19)24-26-6-8(17)2-22-15(13)26/h2-7H,1H3,(H2,19,24)(H,23,27)
InChIKey
RBQPCTBFIPVIJN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tuvusertib
CAS: 1613200-51-3
CID: 90199447
Formula: C16H12F2N8O
MW: 370.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight370.32
XLogP30.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass370.11021336
Monoisotopic Mass370.11021336
Topological Polar Surface Area116 Ų
Heavy Atom Count27
Formal Charge0
Complexity557
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
E1411-01Tuvusertib

Popular Products