Tuvusertib

CAT: 1568-C01664-04Size: 1 gDry Ice: NoHazardous: No

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CAT#:1568-C01664-04Size:1 g

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CAS Number

1613200-51-3

Synonyms

M1774, ATR inhibitor 1

SKU

C01664-5mg

Target

ATM/ATR

Applications

PI3K/Akt/mTOR

Additionnal Information

Tuvusertib (M1774, ATR inhibitor 1) is a potent ATR inhibitor, which exhibits anti-proliferative and anti-tumor effects in cancer cell lines.

Storage Conditions

3 years -20°C powder

Chemical Information

Tuvusertib

Tuvusertib is an orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, tuvusertib selectively inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine protein kinase checkpoint kinase 1 (CHK1). This prevents ATR-mediated signaling, which results in the inhibition of DNA damage checkpoint activation, the disruption of DNA damage repair, and the induction of tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and survival. It is activated by DNA damage caused during DNA replication-associated stress.

CAS Number	1613200-51-3
PubChem CID	90199447
IUPAC Name	2-amino-6-fluoro-N-[5-fluoro-4-(3-methylimidazol-4-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Molecular Formula	C16H12F2N8O
Molecular Weight	370.32
XLogP	0.2
Topological Polar Surface Area	116
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	557

SMILES

CN1C=NC=C1C2=C(C=NC=C2NC(=O)C3=C4N=CC(=CN4N=C3N)F)F

InChI

InChI=1S/C16H12F2N8O/c1-25-7-21-5-11(25)12-9(18)3-20-4-10(12)23-16(27)13-14(19)24-26-6-8(17)2-22-15(13)26/h2-7H,1H3,(H2,19,24)(H,23,27)

InChIKey

RBQPCTBFIPVIJN-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1613200-51-3

CID: 90199447

Formula: C16H12F2N8O

MW: 370.32

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	370.32
XLogP3	0.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	370.11021336
Monoisotopic Mass	370.11021336
Topological Polar Surface Area	116 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	557
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
E1411-01	Tuvusertib

Tuvusertib

Chemical Information

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