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PF-06446846 hydrochloride

CAT: 0013-GTR19203282-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203282-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06446846 hydrochloride is an orally bioavailable small molecule that selectively inhibits PCSK9 synthesis by inducing ribosomal stalling during translation. This mechanism effectively lowers PCSK9 protein levels and has demonstrated activity in both cellular assays and in vivo models for cardiovascular and metabolic disease research.
CAS Number
1632250-50-0
Product Name Alternative
PCSK9, PF 06446846 Hydrochloride, PF 06446846 hydrochloride, PF06446846 hydrochloride, PF06446846 Hydrochloride, PF-06446846 Hydrochloride
Purity
98.11% (May vary between batches)
Solubility
DMSO:225 mg/mL; H2O:90 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL
Smiles
Cl.Clc1cccnc1N ([C@@H]1CCCNC1) C (=O) c1ccc (cc1) -n1nnc2cccnc12
Molecular Formula
C22H20CIN7O.XHCl
Molecular Weight
470.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PF-06446846 hydrochloride
CAS Number1632250-50-0
PubChem CID145925649
IUPAC NameN-(3-chloro-2-pyridinyl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide;hydrochloride
Molecular FormulaC22H21Cl2N7O
Molecular Weight470.4
Topological Polar Surface Area88.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count32
Formal Charge0
Complexity617
SMILES
C1C[C@H](CNC1)N(C2=C(C=CC=N2)Cl)C(=O)C3=CC=C(C=C3)N4C5=C(C=CC=N5)N=N4.Cl
InChI
InChI=1S/C22H20ClN7O.ClH/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21;/h2-3,5-10,12-13,17,24H,1,4,11,14H2;1H/t17-;/m1./s1
InChIKey
AQSJYIVIWBIHOU-UNTBIKODSA-N
Chemical Structure
2D Structure
2D structure of PF-06446846 hydrochloride
CAS: 1632250-50-0
CID: 145925649
Formula: C22H21Cl2N7O
MW: 470.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass469.1184637
Monoisotopic Mass469.1184637
Topological Polar Surface Area88.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity617
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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