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PF-3758309 hydrochloride

CAT: 0013-GTR19169019-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169019-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-3758309 hydrochloride is an orally bioavailable small-molecule inhibitor targeting p21-activated kinase 4 (PAK4), which is frequently overexpressed in cancers. Its inhibition of PAK4 activity disrupts cancer cell proliferation and survival, demonstrating antitumor effects in both cellular assays and in vivo xenograft models across various cancer types.
CAS Number
1279034-84-2
Product Name Alternative
ATP-competitive, Apoptosis, oncogenic, PAK, PAK3, PAK1, PAK4, PAK5, PAK6, inhibit, Inhibitor, growth, signaling, PF 03758309 Hydrochloride, PF 03758309, PF 3758309, PF 3758309 Hydrochloride, PF 3758309 hydrochloride, PF3758309, PF-3758309, PF3758309 hydrochloride, PF3758309 Hydrochloride, PF-3758309 Hydrochloride, PF-03758309, PF03758309 Hydrochloride, PF-03758309 hydrochloride, PF-03758309 Hydrochloride, PF03758309, p21 activated kinases, proliferation, survival, tumor
Field of Research
Cell Biology, Signal Transduction
Purity
98.11% (May vary between batches)
Solubility
DMSO:45 mg/mL (85.38 mM)
Smiles
Cl.CN (C) C[C@@H] (NC (=O) N1Cc2c (Nc3nc (C) nc4ccsc34) n[nH]c2C1 (C) C) c1ccccc1
Molecular Formula
C25H31ClN8OS
Molecular Weight
527.08
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PF-03758309 hydrochloride salt
CAS Number1279034-84-2
PubChem CID76972060
IUPAC NameN-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-d]pyrazole-5-carboxamide;hydrochloride
Molecular FormulaC25H31ClN8OS
Molecular Weight527.1
Topological Polar Surface Area130
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity747
SMILES
CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[C@H](CN(C)C)C5=CC=CC=C5)SC=C2.Cl
InChI
InChI=1S/C25H30N8OS.ClH/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16;/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31);1H/t19-;/m1./s1
InChIKey
DZSGSCZKFHGJNK-FSRHSHDFSA-N
Chemical Structure
2D Structure
2D structure of PF-03758309 hydrochloride salt
CAS: 1279034-84-2
CID: 76972060
Formula: C25H31ClN8OS
MW: 527.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight527.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass526.2030065
Monoisotopic Mass526.2030065
Topological Polar Surface Area130 Ų
Heavy Atom Count36
Formal Charge0
Complexity747
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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