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Abt-288

CAT: 0013-GTR19198332-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198332-01Size:1 mg
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Description
ABT-288 is a potent and selective histamine H3 receptor antagonist researched for cognitive enhancement in Alzheimer's disease models. It has been utilized in both in vitro binding assays and in vivo behavioral studies to investigate its potential for improving memory and learning processes.
CAS Number
948845-91-8
Product Name Alternative
H3 receptor, Histamine Receptor, HistamineReceptor, ABT 288, ABT288, abt-288
Field of Research
Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:6.33 mg/mL (17 mM)
Smiles
CN1C[C@@]2 (N (CC[C@@]2 (C1) [H]) C3=CC=C (C=C3) C4=CC=C (C=C4) N5C (=O) C=CC=N5) [H]
Molecular Formula
C23H24N4O
Molecular Weight
372.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Abt-288

ABT-288 is under investigation in clinical trial NCT01018875 (Efficacy and Safety Study of ABT-288 in Subjects With Mild-to-Moderate Alzheimer's Disease).

CAS Number948845-91-8
PubChem CID24743471
IUPAC Name2-[4-[4-[(3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]phenyl]phenyl]pyridazin-3-one
Molecular FormulaC23H24N4O
Molecular Weight372.5
XLogP3
Topological Polar Surface Area39.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity631
SMILES
CN1C[C@H]2CCN([C@H]2C1)C3=CC=C(C=C3)C4=CC=C(C=C4)N5C(=O)C=CC=N5
InChI
InChI=1S/C23H24N4O/c1-25-15-19-12-14-26(22(19)16-25)20-8-4-17(5-9-20)18-6-10-21(11-7-18)27-23(28)3-2-13-24-27/h2-11,13,19,22H,12,14-16H2,1H3/t19-,22+/m1/s1
InChIKey
GNIRITULTPTAQW-KNQAVFIVSA-N
Chemical Structure
2D Structure
2D structure of Abt-288
CAS: 948845-91-8
CID: 24743471
Formula: C23H24N4O
MW: 372.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.5
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass372.19501140
Monoisotopic Mass372.19501140
Topological Polar Surface Area39.2 Ų
Heavy Atom Count28
Formal Charge0
Complexity631
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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MBS5776257ABT-288
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