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AC-186

CAT: 0013-GTR19198320-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198320-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AC-186 is a selective nonsteroidal agonist for estrogen receptor β (ERβ), exhibiting high affinity for ERβ (EC50 = 6 nM) over ERα (EC50 = 5000 nM) . Its neuroprotective properties have been demonstrated in research models, supporting its use in studying neurodegenerative conditions such as Parkinson's disease.
CAS Number
1421854-16-1
Product Name Alternative
AC186, AC-186, AC 186, ER, Estrogen Receptor, EstrogenReceptor, progestogen Receptor, progestogenReceptor
Field of Research
Metabolism Research
Purity
99.53% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.77 mM) ; DMSO:80 mg/mL (261.16 mM)
Smiles
FC=1C=CC=CC1C2 (C3=CC=C (O) C=C3) CCC (F) (F) CC2
Molecular Formula
C18H17F3O
Molecular Weight
306.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AC-186

structure in first source

CAS Number1421854-16-1
PubChem CID71245042
IUPAC Name4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Molecular FormulaC18H17F3O
Molecular Weight306.3
XLogP5.3
Topological Polar Surface Area20.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity367
SMILES
C1CC(CCC1(C2=CC=C(C=C2)O)C3=CC=CC=C3F)(F)F
InChI
InChI=1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2
InChIKey
HSMUKSLNDJOZQG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AC-186
CAS: 1421854-16-1
CID: 71245042
Formula: C18H17F3O
MW: 306.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.3
XLogP35.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass306.12314965
Monoisotopic Mass306.12314965
Topological Polar Surface Area20.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity367
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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B2980-5AC-186
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