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Ispronicline

CAT: 0013-GTR19197453-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19197453-02Size:1 ml x 10 mM (in DMSO)
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Description
Ispronicline (TC-1734) is a potent and selective partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR), exhibiting high affinity (Ki=11 nM) . This small molecule is utilized in research exploring cognitive enhancement, neuroprotection, and antidepressant mechanisms, with applications in both in vitro binding studies and in vivo behavioral models.
CAS Number
252870-53-4
Product Name Alternative
RJR-1734, α4β2 nAChR, TC 01734, TC1734, TC-1734, TC 1734, TC01734, TC-01734, AZD 3480, AZD3480, AZD-3480, Ispronicline
Field of Research
Neuroscience
Purity
96.49% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.53 mM) ; DMSO:50 mg/mL (213.37 mM)
Smiles
CN[C@@H] (C) C\C=C\c1cncc (OC (C) C) c1
Molecular Formula
C14H22N2O
Molecular Weight
234.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ispronicline

Ispronicline is under investigation in clinical trial NCT00109564 (A Safety and Efficacy Study of Ispronicline (TC-1734-112) in Subjects With Age Associated Memory Impairment (AAMI)).

CAS Number252870-53-4
PubChem CID9824145
IUPAC Name(E,2S)-N-methyl-5-(5-propan-2-yloxy-3-pyridinyl)pent-4-en-2-amine
Molecular FormulaC14H22N2O
Molecular Weight234.34
XLogP2.5
Topological Polar Surface Area34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count17
Formal Charge0
Complexity228
SMILES
C[C@@H](C/C=C/C1=CC(=CN=C1)OC(C)C)NC
InChI
InChI=1S/C14H22N2O/c1-11(2)17-14-8-13(9-16-10-14)7-5-6-12(3)15-4/h5,7-12,15H,6H2,1-4H3/b7-5+/t12-/m0/s1
InChIKey
RPCVIAXDAUMJJP-PZBABLGHSA-N
Chemical Structure
2D Structure
2D structure of Ispronicline
CAS: 252870-53-4
CID: 9824145
Formula: C14H22N2O
MW: 234.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight234.34
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass234.173213330
Monoisotopic Mass234.173213330
Topological Polar Surface Area34.2 Ų
Heavy Atom Count17
Formal Charge0
Complexity228
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
CKA87053-01Ispronicline
T69595-01Ispronicline hemigalactarate
A14183-10Ispronicline 10mg
A14183-25Ispronicline 25mg
A14183-5Ispronicline 5mg
MBS3840239-01Ispronicline (TC-1734, AZD-3480)
A14183-100Ispronicline (TC-1734, AZD-3480) 100mg
A14183-50Ispronicline (TC-1734, AZD-3480) 50mg
A14183-2Ispronicline (TC-1734, AZD-3480) 2mg
A14183-10mM-DIspronicline (TC-1734, AZD-3480) 10mM * 1mL in DMSO

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