Ispronicline

• Description :

  Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR[1][2].

• Product Name Alternative :

  TC-1734; ACD3480

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  NAChR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ispronicline.html

• Purity :

  98.24

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@H](NC)C/C=C/C1=CC(OC(C)C)=CN=C1

• Molecular Formula :

  C14H22N2O

• Molecular Weight :

  234.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515 (1) :7-11.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [252870-53-4]