Ispronicline

CAT: 0804-HY-10063-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10063-01Size:5 mg
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Description
Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR[1][2].
CAS Number
[252870-53-4]
Product Name Alternative
TC-1734; ACD3480
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ispronicline.html
Purity
98.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](NC)C/C=C/C1=CC(OC(C)C)=CN=C1
Molecular Formula
C14H22N2O
Molecular Weight
234.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515 (1) :7-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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