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JAK3i

CAT: 0013-GTR19197438-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19197438-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK3i is a selective covalent inhibitor of JAK3 kinase. It potently suppresses a second, delayed wave of STAT5 phosphorylation, which is critical for T cell cycle progression and proliferation. This tool compound is used in vitro and in vivo to study JAK-STAT signaling in immunology and oncology research.
CAS Number
1918238-72-8
Product Name Alternative
JAK 3i, JAK3, JAK3i, JAK-3i
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.61% (May vary between batches)
Solubility
DMSO:10 mg/mL (28.22 mM)
Smiles
C (OCC) (=O) C=1C2=C (N=CN=C2NC1) C3=CC (NC (C=C) =O) =CC=C3F
Molecular Formula
C18H15FN4O3
Molecular Weight
354.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
CAS Number1918238-72-8
PubChem CID118705186
IUPAC Nameethyl 4-[2-fluoro-5-(prop-2-enoylamino)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
Molecular FormulaC18H15FN4O3
Molecular Weight354.3
XLogP2.4
Topological Polar Surface Area97
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity547
SMILES
CCOC(=O)C1=CNC2=NC=NC(=C12)C3=C(C=CC(=C3)NC(=O)C=C)F
InChI
InChI=1S/C18H15FN4O3/c1-3-14(24)23-10-5-6-13(19)11(7-10)16-15-12(18(25)26-4-2)8-20-17(15)22-9-21-16/h3,5-9H,1,4H2,2H3,(H,23,24)(H,20,21,22)
InChIKey
KNLROUBMVYVLGX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ethyl 4-(5-acrylamido-2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
CAS: 1918238-72-8
CID: 118705186
Formula: C18H15FN4O3
MW: 354.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.3
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass354.11281852
Monoisotopic Mass354.11281852
Topological Polar Surface Area97 Ų
Heavy Atom Count26
Formal Charge0
Complexity547
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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