NVS-SM2

CAT: 0013-GTR19193274-03Size: 100 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19193274-03Size:100 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

NVS-SM2 is an orally active small molecule that enhances SMN2 exon 7 inclusion, elevating SMN protein levels in SMA patient fibroblasts and Δ7 mouse myoblasts. This splicing modulator is a valuable research tool for investigating spinal muscular atrophy mechanisms and therapeutic strategies in both cellular and animal models.

CAS Number

1562333-92-9

Field of Research

Cell Biology, Molecular Biology, Musculoskeletal & Connective Tissue Research

Smiles

CN (C1CC (C) (C) NC (C) (C) C1) c1ccc (nn1) -c1ccc (cc1O) -c1cn[nH]c1

Molecular Formula

C23H30N6O

Molecular Weight

406.52

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Nvs-SM2

CAS Number	1562333-92-9
PubChem CID	136598218
IUPAC Name	2-[6-[methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)phenol
Molecular Formula	C23H30N6O
Molecular Weight	406.5
XLogP	2.9
Topological Polar Surface Area	90
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	30
Formal Charge	0
Complexity	568

SMILES

CC1(CC(CC(N1)(C)C)N(C)C2=NN=C(C=C2)C3=C(C=C(C=C3)C4=CNN=C4)O)C

InChI

InChI=1S/C23H30N6O/c1-22(2)11-17(12-23(3,4)28-22)29(5)21-9-8-19(26-27-21)18-7-6-15(10-20(18)30)16-13-24-25-14-16/h6-10,13-14,17,28,30H,11-12H2,1-5H3,(H,24,25)

InChIKey

XSBJQWNBBMWICJ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1562333-92-9

CID: 136598218

Formula: C23H30N6O

MW: 406.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	406.5
XLogP3	2.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	406.24810960
Monoisotopic Mass	406.24810960
Topological Polar Surface Area	90 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	568
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
GTR19205270-01	NVS-CRF38
GTR19234255-01	NVS-STG2
GTR19212265-01	NVS-MALT1
GTR19222048	NVS PAK1 C
GTR19191739	NVS-PAK1-C
GTR19190838	NVS-CECR2-1
GTR19234863-01	NVS-BPTF-1
GTR19174746-01	NVS-PAK1-1
GTR19244066-01	NVS-CECR2-1
GTR19191508-01	NVS-PI3-4

Alternative Products

Catalog	Name
BA3992-5.1	NVS-SM2
AT162	Sulfadimidine（SM2)
sc-51702	Stat1 (SM2)
30R-3447	SM2-OVA Protein
MBS3846194-01	NVS-CRF38
8120/50	NVS-STG2
HY-160525-01	NVS-VHL720
B1844-5	NVS-SM1

NVS-SM2

Chemical Information

Related Products

Alternative Products

Popular Products