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MYC-RIBOTAC

CAT: 0804-HY-153713-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153713-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research[1]. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 , RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).
UNSPSC
12352005
Target
Apoptosis; c-Myc; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/myc-ribotac.html
Purity
98.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(C(NCCOCCOCCOCCOC4=C(O)C=C(/C=C5SC(NC6=CC=CC=C6)=C(C(OCC)=O)C\5=O)C=C4)=O)=C1)NC7=CC=C(C8=NCCN8)C=C7
Molecular Formula
C55H58N10O11S
Molecular Weight
1067.17
References & Citations
[1]Tong Y, et.al. Programming inactive RNA-binding small molecules into bioactive degraders. Nature. 2023 Jun;618 (7963) :169-179.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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