RNAse L RIBOTAC

• Description:

  RNAse L RIBOTAC (compound C64) is an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. (Blue: RNA ligand (HY-168456) ; Black: linker (HY-130591) ; Pink: Rnase L ligand (HY-168457) ) [1]

• UNSPSC:

  12352005

• Target:

  PROTACs

• Related Pathways:

  PROTAC

• Field of Research:

  Infection

• Smiles:

  O=C(C(C/1=O)=C(NC2=CC=CC=C2)SC1=C/C3=CC=C(OCCOCCN4N=NC(COCCOCCOCCOCCOC5=CC6=NC(C(C7=O)=CC8=C(O7)C=C(N9CCNCC9)C=C8)=CN6C=C5)=C4)C(O)=C3)OCC

• Molecular Formula:

  C55H60N8O13S

• Molecular Weight:

  1073.18

• References & Citations:

  [1]Tang Z, et al. Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region. Nat Commun. 2025 Jan 8;16 (1) :483.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported