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SR 12460

CAT: 0013-GTR19190612-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19190612-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR 12460 is a small molecule that acts as an NBD mimetic, disrupting the IKKβ/NEMO interaction to inhibit NF-κB activation triggered by TNF-α or LPS. It has demonstrated efficacy in cellular assays and reduces acute pulmonary inflammation in mouse models, making it a useful research tool for studying inflammatory signaling pathways.
CAS Number
2055101-66-9
Smiles
O=C (NC1=NC=C (Cl) C=C1) CNCCC=2C=C (F) C=C (F) C2
Molecular Formula
C15H14ClF2N3O
Molecular Weight
325.74
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(5-chloro-2-pyridinyl)-2-[[2-(3,5-difluorophenyl)ethyl]amino]-acetamide
CAS Number2055101-66-9
PubChem CID124117357
IUPAC NameN-(5-chloro-2-pyridinyl)-2-[2-(3,5-difluorophenyl)ethylamino]acetamide
Molecular FormulaC15H14ClF2N3O
Molecular Weight325.74
XLogP2.7
Topological Polar Surface Area54
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity352
SMILES
C1=CC(=NC=C1Cl)NC(=O)CNCCC2=CC(=CC(=C2)F)F
InChI
InChI=1S/C15H14ClF2N3O/c16-11-1-2-14(20-8-11)21-15(22)9-19-4-3-10-5-12(17)7-13(18)6-10/h1-2,5-8,19H,3-4,9H2,(H,20,21,22)
InChIKey
MQWIKNJATTZAPQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(5-chloro-2-pyridinyl)-2-[[2-(3,5-difluorophenyl)ethyl]amino]-acetamide
CAS: 2055101-66-9
CID: 124117357
Formula: C15H14ClF2N3O
MW: 325.74
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight325.74
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass325.0793461
Monoisotopic Mass325.0793461
Topological Polar Surface Area54 Ų
Heavy Atom Count22
Formal Charge0
Complexity352
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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