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AV-101

CAT: 0013-GTR19198194-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198194-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AV-101 (4-Cl-KYN) is a prodrug that acts as an NMDA receptor glycine site antagonist. It exhibits antidepressant-like effects in preclinical models and has been shown to attenuate levodopa-induced dyskinesia in MPTP-lesioned primate models of Parkinson's disease.
CAS Number
153152-32-0
Product Name Alternative
NMDA receptor, L-4-chlorokynurenine, L-4ClKYN, L-4-Cl-KYN, 4-Chlorokynurenine, 4ClKYN, 4-Cl-KYN, (S) -4-Chlorokynurenine, AV 101, AV101, AV-101
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
97.78% (May vary between batches)
Smiles
C (C[C@@H] (C (O) =O) N) (=O) C1=C (N) C=C (Cl) C=C1
Molecular Formula
C10H11ClN2O3
Molecular Weight
242.66
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Av-101

AV-101 has been used in trials studying the treatment of Neuropathic Pain.

CAS Number153152-32-0
PubChem CID9859632
IUPAC Name(2S)-2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
Molecular FormulaC10H11ClN2O3
Molecular Weight242.66
XLogP-1.6
Topological Polar Surface Area106
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count16
Formal Charge0
Complexity285
SMILES
C1=CC(=C(C=C1Cl)N)C(=O)C[C@@H](C(=O)O)N
InChI
InChI=1S/C10H11ClN2O3/c11-5-1-2-6(7(12)3-5)9(14)4-8(13)10(15)16/h1-3,8H,4,12-13H2,(H,15,16)/t8-/m0/s1
InChIKey
HQLHZNDJQSRKDT-QMMMGPOBSA-N
Chemical Structure
2D Structure
2D structure of Av-101
CAS: 153152-32-0
CID: 9859632
Formula: C10H11ClN2O3
MW: 242.66
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight242.66
XLogP3-1.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass242.0458199
Monoisotopic Mass242.0458199
Topological Polar Surface Area106 Ų
Heavy Atom Count16
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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