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AZD6370

CAT: 0013-GTR19198170-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198170-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD-6370 is a glucokinase activator that reduces both fasting and postprandial glucose levels in type 2 diabetes patients, with its efficacy dependent on dosing and food intake. Research applications include studying glucose metabolism and pancreatic beta-cell function in both in vitro and in vivo models, as it does not impair the counterregulatory response to hypoglycemia.
CAS Number
752239-85-3
Smiles
C (NC1=NN (C) C=C1) (=O) C2=CC (OC3=CC=C (S (C) (=O) =O) C=C3) =CC (O[C@H] (CO) C) =C2
Molecular Formula
C21H23N3O6S
Molecular Weight
445.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-(((1S)-2-Hydroxy-1-methylethyl)oxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-(4-(methylsulfonyl)phenoxy)benzamide
CAS Number752239-85-3
PubChem CID11525116
IUPAC Name3-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)-5-(4-methylsulfonylphenoxy)benzamide
Molecular FormulaC21H23N3O6S
Molecular Weight445.5
XLogP1.9
Topological Polar Surface Area128
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity692
SMILES
C[C@@H](CO)OC1=CC(=CC(=C1)OC2=CC=C(C=C2)S(=O)(=O)C)C(=O)NC3=NN(C=C3)C
InChI
InChI=1S/C21H23N3O6S/c1-14(13-25)29-17-10-15(21(26)22-20-8-9-24(2)23-20)11-18(12-17)30-16-4-6-19(7-5-16)31(3,27)28/h4-12,14,25H,13H2,1-3H3,(H,22,23,26)/t14-/m0/s1
InChIKey
RIIDAVMUCMIWKP-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of 3-(((1S)-2-Hydroxy-1-methylethyl)oxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-(4-(methylsulfonyl)phenoxy)benzamide
CAS: 752239-85-3
CID: 11525116
Formula: C21H23N3O6S
MW: 445.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight445.5
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass445.13075664
Monoisotopic Mass445.13075664
Topological Polar Surface Area128 Ų
Heavy Atom Count31
Formal Charge0
Complexity692
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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