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IGF-1R inhibitor-2

CAT: 0013-GTR19189863Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189863Size:5 mg
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Description
IGF-1R inhibitor-2 (example 121) is a selective small molecule inhibitor of the insulin-like growth factor-1 receptor. By blocking IGF-1R signaling, it can reverse oncogenic transformation and promote apoptosis in cancer cells, making it a valuable tool for studying IGF-1R biology in both in vitro and in vivo cancer research models.
CAS Number
1116236-15-7
Field of Research
Immunology & Inflammation; Pharmacology & Drug Discovery, Signal Transduction
Smiles
COc1cc2CCN (C) Cc2cc1Nc1nc (Nc2cccc (F) c2C (N) =O) c2cc[nH]c2n1
Molecular Formula
C24H24FN7O2
Molecular Weight
461.501
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

IGF-1R inhibitor-2
CAS Number1116236-15-7
PubChem CID59442083
IUPAC Name2-fluoro-6-[[2-[(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzamide
Molecular FormulaC24H24FN7O2
Molecular Weight461.5
XLogP3.8
Topological Polar Surface Area121
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity717
SMILES
CN1CCC2=CC(=C(C=C2C1)NC3=NC4=C(C=CN4)C(=N3)NC5=C(C(=CC=C5)F)C(=O)N)OC
InChI
InChI=1S/C24H24FN7O2/c1-32-9-7-13-11-19(34-2)18(10-14(13)12-32)29-24-30-22-15(6-8-27-22)23(31-24)28-17-5-3-4-16(25)20(17)21(26)33/h3-6,8,10-11H,7,9,12H2,1-2H3,(H2,26,33)(H3,27,28,29,30,31)
InChIKey
FDCFRUWNFPYFBR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of IGF-1R inhibitor-2
CAS: 1116236-15-7
CID: 59442083
Formula: C24H24FN7O2
MW: 461.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.5
XLogP33.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass461.19755120
Monoisotopic Mass461.19755120
Topological Polar Surface Area121 Ų
Heavy Atom Count34
Formal Charge0
Complexity717
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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