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Taletrectinib free base

CAT: 0013-GTR19189601-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189601-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Taletrectinib free base (AB-106) is a potent, selective, and orally active small molecule inhibitor targeting ROS1 and NTRK kinases. It demonstrates low nanomolar IC50 values against wild-type ROS1, NTRK1/2/3, and several crizotinib-resistant ROS1 mutants like G2032R. This inhibitor is utilized in preclinical oncology research for studying targeted therapies in both cellular and animal models of ROS1- or NTRK-driven cancers.
CAS Number
1505514-27-1
Product Name Alternative
ROS Kinase, ROS1, ROSKinase, Taletrectinib, Taletrectinib free base, AB-106freebase, DS-6051b, DS-6051b free base, IBI344, IBI-344, IBI-344 free base, IBI 344
Field of Research
Signal Transduction
Purity
99.87% (May vary between batches)
Solubility
DMSO:55 mg/mL (135.65 mM)
Smiles
N ([C@H] (C) C1=CC (F) =CC=C1) C2=NN3C (=CN=C3C=C2) C4=CC=C (OC[C@@H] (C) N) C=C4
Molecular Formula
C23H24FN5O
Molecular Weight
405.47
Storage Conditions
-20°C
Notes
For research use only.

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