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KN1022

CAT: 0013-GTR19188294-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188294-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KN1022 is a potent small molecule inhibitor that selectively targets the platelet-derived growth factor (PDGF) receptor, blocking its phosphorylation with an IC50 of 0.26 μM. It is a valuable research tool for studying PDGF signaling pathways in cellular models and has been utilized in investigations related to fibrosis and proliferative diseases.
CAS Number
205255-11-4
Product Name Alternative
PDGFR, KN1022, KN-1022, KN 1022
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.68% (May vary between batches)
Solubility
DMSO:11 mg/mL (25.09 mM)
Smiles
O (C) C1=CC=2C (=NC=NC2C=C1OC) N3CCN (C (NC4=CC=C (N (=O) =O) C=C4) =O) CC3
Molecular Formula
C21H22N6O5
Molecular Weight
438.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-(6,7-dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide
CAS Number205255-11-4
PubChem CID9911005
IUPAC Name4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-nitrophenyl)piperazine-1-carboxamide
Molecular FormulaC21H22N6O5
Molecular Weight438.4
XLogP2.4
Topological Polar Surface Area126
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count32
Formal Charge0
Complexity647
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=O)NC4=CC=C(C=C4)[N+](=O)[O-])OC
InChI
InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28)
InChIKey
ZIFCMJKHIXABHJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(6,7-dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide
CAS: 205255-11-4
CID: 9911005
Formula: C21H22N6O5
MW: 438.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight438.4
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass438.16516782
Monoisotopic Mass438.16516782
Topological Polar Surface Area126 Ų
Heavy Atom Count32
Formal Charge0
Complexity647
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T60110-01KN1022

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